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lpdV [2017-8-11 16:0:3]
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lpdV [2017-8-11 16:0:3]

2-oxoisovalerate dehydrogenase (E3 subunit, dihydrolipoamide dehydrogenase)
Locus
BSU24060
Isoelectric point
4.89
Molecular weight
48.51 kDa
Protein length
457 aa Sequence Blast
Gene length
1371 bp Sequence Blast
Function
utilization of branched-chain keto acids
Product
2-oxoisovalerate dehydrogenase (E3 subunit, dihydrolipoamide dehydrogenase)
Essential
no
E.C.
1.8.1.4
Synonyms
yqiV,bkd
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Amino acid/ nitrogen metabolism → Utilization of amino acids → Utilization of branched-chain amino acids

    • Gene

    Coordinates
    2,500,104 → 2,501,528

    The protein

    Catalyzed reaction/ biological activity

  • Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH (according to Swiss-Prot)

    • Protein family

  • class-I pyridine nucleotide-disulfide oxidoreductase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • AcoL, PdhD

    • Structure

  • 2YQU (from Thermus thermophilus (hb8 mutant), 42% identity, 55% similarity)

    • Expression and Regulation

    Operons

    Genes
    ptb-bcd-buk-lpdV-bkdAA-bkdAB-bkdB
    Description
    PubMed

    Sigma factors

  • SigL: sigma factor, PubMed, in SigL regulon

    • Regulatory mechanism

  • BkdR: activation, PubMed, in BkdR regulon
  • CodY: repression, PubMed, in CodY regulon

    • Regulation

  • induced in the presence of isoleucine or valine (BkdR) PubMed
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    Biological materials

    Mutant

  • MGNA-C379 (yqiV::erm), available at the NBRP B. subtilis, Japan

    • References

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